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Lauric Acid

Name: Lauric Acid
Brand: Selleck Chemicals
SKU: S4726
Rating: 5 (1 reviews)

Synonyms: dodecanoic acid, N-Dodecanoic acid, Dodecylic acid

Catalog No.S4726 Purity:99.57%

Lauric Acid (dodecanoic acid, N-Dodecanoic acid, Dodecylic acid) is a saturated medium-chain fatty acid with a 12-carbon backbone. Lauric acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil.

Lauric Acid Chemical Structure

CAS No. 143-07-7

Purity & Quality Control

Batch: Purity: 99.57%

99.57

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Biological Activity

Description	Lauric Acid (dodecanoic acid, N-Dodecanoic acid, Dodecylic acid) is a saturated medium-chain fatty acid with a 12-carbon backbone. Lauric acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil.

In vitro
In vitro	Lauric acid induces apoptosis in Caco-2 (p<0.05) and IEC-6 cells (p<0.05). In Caco-2 cells, lauric acid reduces GSH availability and generated ROS compared to butyrate(p < 0.05). Lauric acid reduces Caco-2 and IEC-6 cells in G0/G1 and arrested cells in the S and G2/M phases. Lauric acid induces apoptosis in IEC-6 cells compared to butyrate(p < 0.05). Lauric acid induces high levels of ROS^[1].
Cell Research	Cell lines	Caco-2 and IEC-6 cell lines
	Concentrations	0.1, 0.3, 0.5 and 1 mM
	Incubation Time	24, 48, 72, and 96 h
	Method	Cell lines are harvested by enzymatic dissociation and seeded into 24-well tissue culture plates at 2.5 × 10⁵ and 1.5 × 10⁵ cells/ml, respectively. After 24 h of incubation, the medium is replaced with 1 ml of complete DMEM containing freshly prepared (50 mM )Lauric acid, conjugated to 0.4% FAF-BSA to final concentrations of 0.1, 0.3, 0.5 and 1 mM and compared to NaB (5 mM ) with 50 μl of 0.4% FAF-BSA as a vehicle control and incubated in a humidified atmosphere at 37℃ in 5% CO₂ and, after enzymatic dissociation, assayed at 24, 48, 72, and 96 h. All experimental studies are undertaken in triplicate and measured in duplicate.

References

[1] Fauser JK, et al. Chemotherapy. 2013, 59(3):214-24.

Chemical Information & Solubility

Molecular Weight	200.32	Formula	C₁₂H₂₄O₂
CAS No.	143-07-7	SDF	Download Lauric Acid SDF
Smiles	CCCCCCCCCCCC(=O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 40 mg/mL ( (199.68 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 40 mg/mL

Water : 20 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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